Quotient Clinical
Providing tailored solutions to support your early drug development programs

Drug Product Optimisation

An effective drug product must deliver to the right place, at the right time and at the right concentration to have a beneficial therapeutic effect. For oral medicines, this should ideally be in a once- to twice-daily dosing regimen.   New Chemical Entities (NCEs)  emerging from the industry R&D pipeline present increasing challenges to achieving this profile, with sub-optimal solubility and/or permeability characteristics often encountered.

Rudimentary formulations used in the First-in-Human (FIH) study have to be transitioned to formulations suitable for later stage development. Drug products must be optimised to ensure marketplace viability.

We have developed a suite of innovative services that significantly enhance the drug product optimisation process for oral medicines.

  • EnterionTM is a proprietary technology that enables us to understand drug absorption, metabolism and transport within the gastrointestinal (GI) tract.
  • RapidFACTTM (Rapid Formulation development And Clinical Testing) offers a new paradigm to screen, select and validate new formulations in man. Drug products can then be manufactured at volumes to support further early development studies.
  • Pharmacoscintigraphy enables the performance of a drug product to be visualised as it passes through the gut.

Our thorough understanding of GI physiology and anatomy and their impact on drug absorption underpins all our approaches.