Pharmacokinetics and toxicokinetics
Quotient Bioresearch have many years’ experience carrying out pharmacokinetic, pharmacodynamic and toxicokinetic studies for all stages of drug development.
Our trained and experienced pharmacokineticists use industry standard Kinetica™ and WinNonLin™ applications for data modelling, giving you access to a complete bioanalytical pharmacokinetic/toxicokinetic (PK/TK) service to support your pre-clinical and clinical studies.
- Preclinical investigations - as well as developing and validating bioanalytical methods in pre-clinical safety studies, we can analyse data and prepare toxicokinetic appendices to toxicology study reports. We will present your data in clear tables and graphs and provide expert advice on candidate selection
- Clinical investigations - our high-throughput, highly accurate techniques are ideally suited to the large numbers of samples generated by clinical trials. Using the latest laboratory information systems we can carry out pharmacokinetic analysis to your preferred format as soon as data is verified
- Flexibility - we can carry out clinical studies from phases I to IV across a broad range of therapeutic applications, developing bespoke methods when required. We can carry out standard data analysis in-house and have access to the very best specialist statisticians and kineticists for more detailed analysis
- High quality - we are accredited to ISO17025, GLP, GCP and cGMP standards and can carry out non-compliant studies as well - but without compromising our own high standard of scientific excellence.
We also have expertise in compartmental modeling which enables the simulation of a range of scenarios such as:
- multiple dosing at different dose levels and intervals
- effect of formulation changes
- prediction of the pharmacokinetic profiles of alternative compounds with different absorption elimination properties.
The application of PK/PD (pharmacokinetic/pharmacodynamic) models can add further value by linking the pharmacodynamic (PD) effect to the pharmacokinetic (PK) properties of a compound and the subsequent prediction of the pharmacodynamic responses expected for differing dosage regimens.
Contact us for more information and to discuss your specific needs.
Further reading
The following downloads are available as .pdf files, or get in touch for a hard copy.
- Pharmacokinetics and toxicokinetics - further information on Quotient Bioresearch’s kinetic analysis services.