Regulatory DMPK
Understanding metabolism and pharmacokinetic properties form an important part of the evaluation of candidate drugs in development. Quotient Bioresearch has many years’ experience conducting and interpreting DMPK studies applying cutting-edge radiosynthesis and bioanalytical techniques.
- Cutting edge techniques – customised radiochemical synthesis, analytical techniques pioneered by our scientists for high-turnover analysis and the very latest laboratory equipment allied with enthusiastic and experienced staff mean bespoke testing with accurate results. Study types include:
- Absorption and bioavailability
- Excretion/balance
- Bilary excretion and enterohepatic circulation
- Protein binding
- Metabolite profiling (radio-HPLC and LC-MS/MS)
- Metabolite identification (LC-MS/MS and NMR)
- Quantitative whole body autoradiography (QWBA)
- Species comparison and in vitro / in vivo evaluations
- Project management
- Analysis and approval
Contact us for more information and to discuss your specific needs.