14C Custom Radiosynthesis

With world class facilities and chemists having over 1,600 man-years' experience in radiosynthesis, Quotient Bioresearch offers unparalleled resources for the custom synthesis of isotopically labelled compounds.

Types of Preparation

Most organic compounds including: aromatics, heterocyles, polymers, peptides and proteins, fermentations, volatile compounds, and chiral compounds.

Standard Quality Control Specifications

Mass spectrometry for structural analysis and for determining specific activity
TLC and HPLC for determining radiochemical purity
1H NMR for structural information
Product specification sheet and analytical scans are provided for each preparation

Additional Extras

Chemical purity, chiral purity, capillary electrophoresis, ultraviolet-visible spectroscopy, and Fourier transform infrared spectroscopy (FTIR)

QC Equipment and Techniques

HPLC	Agilent HP1100 and 1200
NMR	Bruker Avance, 400 MHz
FTIR	Mattson
Mass Spectrometry	Kratos MS25 RF (FAB+ and FAB-) Kratos MS80 RFA (El) Jeol JMS-DZ3000 (Cl and El) VG TRIO2000 (Cl and El) MicromassQToF2 (ES-, ES+, and MS-MS)
Radio-gas chromatography	Hewlett Packard 6890 with FID or TCD and radiodetectors
Capillary electrophoresis	Agilent
Radio-TLC	Bioscan AR2000

Additional Services

Consultancy, stability studies, storage, reanalysis, repurification, worldwide shipment, partial and drop shipments, weekly updates, full synthetic write-up and others as requested.

Carbon-14 GMP

Good Manufacturing Practice (GMP); Accredited by the Medicines and Healthcare Products Regulatory Agency (MHRA)

Contact us for more information or to discuss your specific needs

TLC - Thin Layer Chromatography; HPLC - High Performance Liquid Chromatography, NMR - Nuclear Magnetic Resonance.