Chemistry & Metabolism
Integrating chemistry & metabolism to accelerate your product development

14C Custom Radiosynthesis

With world class facilities and chemists having over 1,600 man-years' experience in radiosynthesis,  Quotient Bioresearch offers unparalleled resources for the custom synthesis of isotopically labelled compounds.

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Types of Preparation

Most organic compounds including: aromatics, heterocyles, polymers, peptides and proteins, fermentations, volatile compounds, and chiral compounds.

Standard Quality Control Specifications

  • Mass spectrometry for structural analysis and for determining specific activity
  • TLC and HPLC for determining radiochemical purity 
  • 1H NMR for structural information 
  • Product specification sheet and analytical scans are provided for each preparation

Additional Extras

Chemical purity, chiral purity, capillary electrophoresis, ultraviolet-visible spectroscopy, and Fourier transform infrared spectroscopy (FTIR)

QC Equipment and Techniques

HPLCAgilent HP1100 and 1200
NMRBruker Avance, 400 MHz
Mass Spectrometry

Kratos MS25 RF (FAB+ and FAB-)

Kratos MS80 RFA (El) Jeol

JMS-DZ3000 (Cl and El)

VG TRIO2000 (Cl and El)

MicromassQToF2 (ES-, ES+, and MS-MS)  

Radio-gas chromatographyHewlett Packard 6890 with FID or TCD and radiodetectors
Capillary electrophoresisAgilent
Radio-TLCBioscan AR2000

Additional Services

Consultancy, stability studies, storage, reanalysis, repurification, worldwide shipment, partial and drop shipments, weekly updates, full synthetic write-up and others as requested.

Carbon-14 GMP

Good Manufacturing Practice (GMP); Accredited by the Medicines and Healthcare Products Regulatory Agency (MHRA)

Contact us for more information or to discuss your specific needs

TLC - Thin Layer Chromatography; HPLC - High Performance Liquid Chromatography, NMR - Nuclear Magnetic Resonance.