Custom Radiolabelling
With world class facilities and chemists having over 1,600 man-years' experience in radiosynthesis, Quotient Bioresearch offers unparalleled resources for the custom synthesis of isotopically labelled compounds.
For Carbon-14 we offer the following Quality Services
- Good Manufacturing Practice (GMP); Accredited by the Medicines and Healthcare Products Regulatory Agency (MHRA)
- GMP Guidelines; Similar to accredited GMP but with the flexibility to define your exact requirements. Provides more control to meet internal QA requirements for human studies
Types of Preparation
Most organic compounds including: aromatics, heterocyles, polymers, peptides and proteins, fermentations, volatile compounds, and chiral compounds.
Standard Quality Control Specifications
- Mass spectrometry for structural analysis and for determining specific activity
- TLC and HPLC for determining radiochemical purity
- 1H NMR for structural information
- Product specification sheet and analytical scans are provided for each preparation
Additional Extras
Chemical purity, chiral purity, capillary electrophoresis, ultraviolet-visible spectroscopy, and Fourier transform infrared spectroscopy (FTIR)
QC Equipment and Techniques
| HPLC | Agilent HP1100 and 1200 |
| NMR | Bruker Avance, 400 MHz |
| FTIR | Mattson |
| Mass Spectrometry | Kratos MS25 RF (FAB+ and FAB-) Kratos MS80 RFA (El) Jeol JMS-DZ3000 (Cl and El) VG TRIO2000 (Cl and El) MicromassQToF2 (ES-, ES+, and MS-MS) |
| Radio-gas chromatography | Hewlett Packard 6890 with FID or TCD and radiodetectors |
| Capillary electrophoresis | Agilent |
| Radio-TLC | Bioscan AR2000 |
Additional Services
Consultancy, stability studies, storage, reanalysis, repurification, worldwide shipment, partial and drop shipments, weekly updates, full synthetic write-up and others as requested.
Contact us for more information or to discuss your specific needs
TLC - Thin Layer Chromatography; HPLC - High Performance Liquid Chromatography, NMR - Nuclear Magnetic Resonance.