Regulatory DMPK

Understanding metabolism and pharmacokinetic properties form an important part of the evaluation of candidate drugs in development. Quotient Bioresearch has many years’ experience conducting and interpreting DMPK studies applying cutting-edge radiosynthesis and bioanalytical techniques.

Cutting edge techniques – customised radiochemical synthesis, analytical techniques pioneered by our scientists for high-turnover analysis and the very latest laboratory equipment allied with enthusiastic and experienced staff mean bespoke testing with accurate results. Study types include:

Absorption and bioavailability
Excretion/balance
Bilary excretion and enterohepatic circulation
Protein binding
Metabolite profiling (radio-HPLC and LC-MS/MS)
Metabolite identification (LC-MS/MS and NMR)
Quantitative whole body autoradiography (QWBA)
Species comparison and in vitro / in vivo evaluations
Project management
Analysis and approval

Contact us for more information or to discuss your specific needs

DMPK - Drug Metabolism and Pharmacokinetics; HPLC - High Performance Liquid Chromatography; LC-MS - Liquid Chromatography-Mass Spectrometry; NMR - Nuclear Magnetic Resonance.